TCF12 (transcription factor 12)

TCF12 is mutated in anaplastic oligodendroglioma

Anaplastic oligodendroglioma (AO) are rare primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC and FUBP1. We also identified recurren...

metabolic syndrome and mitochondrial transcription factor a

S08-12 The ETS family transcription factor, ETV2, activates a hierarchy of endothelial and myeloid transcription factors

intracellular components have been identified in both invertebrate and vertebrate, extracellular regulation that allows the morphogenesis cell mass maintaining the epithelial integrity is largely unknown. Here, we present Nectin2, a cell adhesion molecule belonging to the immunoglobulin family has an essential role in the apical constriction. Nectin2 expression is spatially and temporally regul...

Regulation of corneal keratin-12 gene expression by the human Krüppel-like transcription factor 6.

PURPOSE The keratin-12 (K12) protein is essential for the integrity of the corneal epithelium. This study was conducted to investigate the possible involvement of Krüppel-like factor 6 (KLF6) in the corneal regulation of K12 gene expression, in view of the presence of one KLF6 potential binding site in the human K12 promoter and the known role of KLF6 in regulating keratin gene expression. ME...

MicroRNA-204 inhibits cell migration and invasion in human cervical cancer by regulating transcription factor 12

Deregulated microRNAs (miRs) and their roles in carcinogenesis have attracted great attention in recent years. Although miR-204 was reportedly dysregulated in various types of cancer, its function and mechanism in cervical cancer remain unknown. The present study focused on the expression and mechanisms of miR-204 in cervical cancer development. Expression of miR-204 in cervical cancer tissues ...